ISBN:  Unavailable

Category: Unavailable

Page count: 140

Cholic acid derivatives, because of their unique structures and biological compatibility, are potentially useful in a range of applications as therapeutic agents, antimicrobial peptide mimics, and building blocks in supramolecular chemistry. Herein, a rapid, modular synthesis of facial amphiphiles from cholic acid is described. The synthesis offers a systematic way to vary the hydrophile-lipophile balance of cholate derivatives. A synthesis of 3-[Alpha] imidazole cholate derivative is also described. If assembled on a covalent scaffold, the resulting molecules would catalyze acyl-transfer reactions. A dendric molecular basket was found to form a reversed-micelle-like basket conformation, which could enrich DMSO in the cavity from a mostly nonpolar solvent mixture. DMSO-enrichment by cholates is a cooperative phenomenon, all six cholates work together to enrich DMSO. These molecules are potentially useful in molecular recognition and enzyme mimics.