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Abstract: Computer-aided design and computer-aided manufacturing (CAD-CAM) enable subtractive or additive fabrication of temporary fixed dental prostheses (FDPs). The present in-vitro study aimed to compare the fracture resistance of both milled and additive manufactured three-unit FDPs and bar-shaped, ISO-conform specimens. Polymethylmethacrylate was used for subtractive manufacturing and a light-curing resin for additive manufacturing. Three (bars) and four (FDPs) different printing orientations were evaluated. All bars (n = 32) were subjected to a three-point bending test after 24 h of water storage. Half of the 80 FDPs were dynamically loaded (250,000 cycles, 98 N) with simultaneous hydrothermal cycling. Non-aged (n = 40) and surviving FDPs (n = 11) were subjected to static loading until fracture. Regarding the bar-shaped specimens, the milled group showed the highest flexural strength (114 ± 10 MPa, p = 0.001), followed by the vertically printed group (97 ± 10 MPa, p