Zbornik je sestavljen iz dveh vsebinskih delov. Prvi del so zbrana dela študentov medicine, v katerih predstavijo specifike različnih področij od prenatalne diagnostike, rokovanja z novorojenci, prizadetosti organskih sistemov do sodobnih pristopov zdravljenja cistične fibroze. V drugem delu so zbrani povzetki predavanj s kongresa. Slavka Grmek Ugovšek predstavi Društvo za cistično fibrozo Slovenije, Alja Klara Ugovšek deli osebno izkušnjo življenja s cistično fibrozo. Vključena so predavanja strokovnjakov z različnih področij pediatrije: dr. Maja Tomazin - pulmologija, dr. Jernej Brecelj - gastroenterologija, Lidija Skočir - respiratorna fizioterapija. Z vidika interne medicine nam spregovorita dr. Matjaž Fležar in dr. Barbara Salobir o zdravljenju in življenju s cistično fibrozo. Pripravo na presaditev pljuč ter presaditev pljuč pa predstavita dr. Matjaž Turel in dr. Tomaž Štupnik.

The impairment of fibrinolysis through elevation of plasminogen activator inhibitor (PAI) activity could be associated with increased risk for ischaemic heart disease in patients with diabetes mellitus. One of the most important treatment strategy is appropriate diet with dietary fiber supplementation. Oat husk fiber has been shown to decrease normal PAI activity in 11 health volunteers. The aim of our study was to examine the influence of oat husk supplementation on fibrinolytic and metabolic variables in survivors of myocardial infarction with diabetes mellitus type 2, who have elevated PAI activity. 43 survivors of myocardial infarction with diabetes type 2 (35 males and 7 females, aged 51 to 78 years, mean age 63.9+-6.6, with body mass index BMI 29.6+-4.1 kg/square meter) were randomly assigned to two groups of comparable age and BMI. Patients from treated group consumed 5.4 g of oat husk fiber tablets in addition to their regular diet for 6 weeks (adaptation period). Patients in control group maintained their regular diet only. Blood samples were collected at the entry of the study, after 6 weeks, after 4 weeks and after 4 weeks of washout period. We measured total and HDL cholesterol, triglycerides, serum glucose, insulin, glycosilated haemoglobin, lipoprotein(a), plasma tissue plasminogen activator (t-PA) activity and antigen, PAI activity and antigen, plasminogen activity, fibrinogen and euglobulin clot lysis time. There were no significant differences in basal levels of BMI, PAI activity and antigen and t-PA activity and antigen between both groups. We did not demonstrate any significant change of PAI activity and antigen levels following the 4 weeks of 10.8 g husk fiber supplement per day. Oat husk tablets decreased LDL cholesterol levels (for 18 percent), the concomitant decrease in control group was lower (for 7 percent). There was an increase in HDL cholesterol in both groups during the study.(trunc.).

Background. Exercise intolerance, a key symptom of chronic heart failure, has been linked to peripheral derangements, and marked endothelial dysfunction (i.e. the inability of endothelium to mediate a proper vasodilatatory responseto physiologic stimuli) has been postulated to be one of the main causes. We hypothesized that supervised aerobic leg training improves endothelial function in the upper limb vessels. Methods. In our prospective study, 24 patients (3 women, 21 men, aged SO-80 years) with chronic heart failure were randomized to a control or a training group, which attended one-hour training sessions 3 times a week for 8 weeks. Before and after the training period, clinical and biochemical parameters, exercise capacity as well as endothelial dysfunction were determined. Endothelial dysfunction was assessed by high-resolution ultrasound measurements of brachial artery diameter and peak flow velocity at rest, after reactive hyperemia (causing flow-mediated endothelium-dependent dilation), and after gylceriltrinitrate administration (causing endothelium-independent vasodilatation). Results. Endothe(ium-dependent vasodilatation improved in training patients from 4.2 +-2.1 % (mean f standard deviation) to 7.7 +- 2.3% (p