This report investigates whether self-assessment tools can help older drivers make the right choices about their driving. It tells us something about how our abilities change with age and how this impacts on driving skills, how you can go about testing for these, and whether self-assessment tools can help drivers self-regulate. Most importantly this report tells us what self-assessment tools can do, what they cannot do and what they should include if they are to be helpful. The right self-assessment tools can provide useful feedback on driving strengths, weaknesses and future mobility options.

Abstract: Background: Clinicians around the world perform clinical research in addition to their high workload. To meet the demands of high quality Investigator Initiated Trials (IITs), Clinical Trial Units (CTUs) (as part of Academic Research Institutions) are implemented worldwide. CTUs increasingly hold a key position in facilitating the international mutual acceptance of clinical research data by promoting clinical research practices and infrastructure according to international standards. Aim: In this project, we aimed to identify services that established and internationally operating CTUs - members of the International Clinical Trial Center Network (ICN) - consider most important to ensure the smooth processing of a clinical trial while meeting international standards. We thereby aim to drive international harmonization by providing emerging and growing CTUs with a resource for informed service range set-up. Methods: Following the AMEE Guide, we developed a questionnaire, addressing the perceived importance of different CTU services. Survey participants were senior representatives of CTUs and part of the ICN with long-term experience in their field and institution. Results: Services concerning quality and coordination of a research project were considered to be most essential, i.e., Quality management, Monitoring and Project management, followed by Regulatory & Legal affairs, Education & Training, and Data management. Operative services for conducting a research project, i.e., Study Nurse with patient contact and Study Nurse without patient contact, were considered to be least important. Conclusion: To balance the range of services offered while meeting high international standards of clinical research, emerging CTUs should focus on offering (quality) management services and expertise in regulatory and legal affairs. Additionally, education and training services are required to ensure clinicians are well trained on GCP and legislation. CTUs should evaluate whether the expertise and resources are available to offer operative services

Abstract: Das "Manual Systematische Recherche für Evidenzsynthesen und Leitlinien" richtet sich vor allem an Leitlinien-Ersteller und Leitlinien-Berater mit dem Ziel, sie über eine qualifizierte Recherche zu informieren und bei gegebener praktischer Anleitung (z. B. im Rahmen eines Leitlinien-Seminars) zu einer eigenständigen Recherche zu befähigen. Die Grundlagen dieses Manuals bilden international anerkannte Standards für die Durchführung von Recherchen. Das Manual ergänzt und vertieft das AWMF-Regelwerk zur Erstellung von Leitlinien, im Besonderen die Kapitel "Planung und Organisation" und "Leitlinien-Entwicklung" mit den Abschnitten "Formulierung von klinisch relevanten Fragestellungen", "Systematische Evidenzbasierung", "Recherche, Auswahl und methodische Bewertung bereits vorhandener Leitlinien und deren Aufbereitung" sowie "Recherche, Auswahl und methodische Bewertung von Literatur und deren Aufbereitung"