Designed as a general introduction to Christian liturgy, this book explores the meaning, history, and practice of worship in Eastern and Western, Catholic and Protestant traditions. Its chapters cover the theology of worship, the historical development of Eucharist and the Prayer Offices, the lectionary and customs of the church year, other sacramental rites, and the use of music and the arts. As such, it is a perfect textbook for students seeking to understand the basics of liturgical worship, as well as a reliable guide for worship leaders.

Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.

Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.

In June 1940, as Nazi troops marched into Paris, the Soviet Red Army marched into Lithuania, Latvia, and Estonia; seven weeks later, the USSR Supreme Soviet ratified the Soviet takeover of these states. For half a century, Soviet historians insisted that the three republics had voluntarily requested incorporation into the Soviet Union. Now it has become possible to examine the events of that tumultuous time more carefully. Alfred Erich Senn, the author of books on the formation of the Lithuanian state in 1918-1920 and on the reestablishment of that independence in 1988-1991, has produced a fascinating account of the Soviet takeover, juxtaposing a picture of the disintegration and collapse of the old regime with the Soviets' imposition of a new order. Discussing the historiography and the living memory of the events, he uses the image of a "shell game" that focused attention on the work of a supposedly "non-communist" government while in the hothouse conditions of military occupation Moscow undermined the state's independent institutions and introduced a revolution from above.

This unique synthesis of chapters from top experts in their fields targets the unique and significant area of cancer prevention for different types of cancers. Perspective readers are invited to go through novel ideas and current developments in the field of molecular mechanisms for cancer prevention, epidemiological studies, antioxidant therapies and diets, as well as clinical aspects and new advances in prognosis and avoidance of cancer. The primary target audience for the book includes PhD students, researchers, biologists, medical doctors and professionals who are interested in mechanistic studies on cancer prevention and translational benefits for optimized cancer treatment.