Disorders of Hemoglobin stands tall as the definitive work on the genetics, pathophysiology, and clinical management of hemoglobinopathies and thalassemia. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the world authorities on the science and clinical management of these disorders and created the authoritative textbook for researchers and clinicians alike.Authors describe the scientific basis of clinical features and provide clinicians with a clear background of disorders they treat and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference on hemoglobinopathies for hematologists, pediatricians, clinical investigators, and geneticists worldwide.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2–21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues.

Cancer Nursing: Principles and Practice, Eighth Edition continues as the gold standard in oncology nursing. With contributions from the foremost experts in the field, it has remained the definitive reference on the rapidly changing science and practice of oncology nursing for more than 25 years. Completely updated and revised to reflect the latest research and developments in the care of patients with cancer, the Eighth Edition includes new chapters on the biology of cancer, sleep disorders, and palliative care across the cancer continuum. The Eighth Edition also includes significant updates to the basic science chapters to reflect recent increases in scientific knowledge, especially relating to genes and cancer. Also heavily revised are the sections devoted to the dynamics of cancer prevention, detection, and diagnosis, as well as treatment, oncologic emergencies, end of life care, and professional and legal issues for oncology nurses.

A Doody's Core Title 2012 This new comprehensive reference provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Authored by some of the world« leading cancer rehabilitation experts and oncology specialists, the principles section provides primer level discussions of the various cancer types and their assessment and management. The practice section thoroughly explores the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer.This groundbreaking volume enables the entire medical team to provide superior care that results in a better quality of life for cancer survivors. Features include: Multi-specialty editorship and authorship from physiatry, oncology, physical therapy, occupational therapy,and related disciplines. Focus on therapeutic management of cancer-related impairments and complications. In-depth treatment of the medical, neurologic, musculoskeletal, and general rehabilitation issues specific to this patient population.

This monograph extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. It explains how complex systems, contrary to expectations, can spontaneously exhibit degrees of order.

Advances in Cancer Research

Cancer Genetics is a collection of chapters covering the key recent developments in cancer genetics which have an impact on clinical care. The target audience will be physicians and scientists who need to be apprised on the most recent developments in the field.

The mortality rate from cancer hasn't changed in 60 years despite the billions invested to find a cure. Avoiding Cancer One Day At A Time provides solid, practical advice for preventing cancer by avoiding carcinogens and implementing lifestyle/dietary practices that modify cancer causing factors. Combining their experience in family medicine and epidemiology with their passion for disease prevention, the authors provide the most up to date and effective advice for preventing cancer from developing in ourselves and our loved ones. Many ?how to? examples for preventing cancer by being environmentally aware, avoiding infections, living the proper lifestyle and getting the proper nutrition are provided. Chapter by chapter summaries and listings of the latest cancer prevention web sites are great references. Worksheets assist readers in implementing the advice in very tangible ways, and the recipe collection of cancer avoiding meals is a winner!