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Frontotemporal Dementia Associated with Intrathecal Antibodies Against Axon Initial Segments
by Dominique Endres, Andrea Schlump, Kathrin Alexandra Nickel, Benjamin Berger, Kimon Runge, Thomas Lange, Katharina Domschke, Horst Urbach, Nils Venhoff, Philipp Tobias Meyer, Joachim Karl Brumberg, Harald Prüß, Ludger Tebartz van Elst · 2023
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Abstract: A recent publication by del Campo and colleagues (2022) summarized the current evidence of cerebrospinal fluid (CSF) biomarkers in frontotemporal dementia (FTD).1 In addition to the established CSF biomarkers of neurodegeneration,1 autoimmune mechanisms could be associated with FTD.2, 3 Underlying autoimmune encephalitis or autoimmune psychosis can be treated with immunotherapies.3, 4 The present article illustrates a paradigmatic case study in which routine diagnostic findings revealed the presence of neurodegenerative FTD5 and novel neuronal autoantibodies leading to the conclusion of possibly autoimmune-modulated neurodegenerative FTD