Account of the Cockburn family of Scotland, the Cockburns abroad, and some unidentified branches.

A unique collection of headteachers' voices discussing leading and managing mediocre teachers and their colleagues. It explores the dilemmas they face as they cope with teachers' personal and professional lives, aging colleagues, accountability and government directives and provides significant insights into the complexities of being a leader.

"What is a nongenotoxic carcinogen?" This question recurred through out the Ernst Schering Research Foundation Workshop on nongeno toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com mon mechanisms include hormonal imbalance resulting in thyroid tu mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book.

A theoretical and empirical study of the structural-acoustic response and sound transmission properties of fuselage structures is described. The external fluctuating pressure environments discussed are boundary layer turbulence, jet noise and reverberant acoustic fields. In order to investigate the complete behavior of the fuselage, equivalent structural models are analyzed whose combined characteristics represent the complex fuselage structure throughout the entire frequency response range of interest. The structure and interior sound field are treated throughout as a coupled dynamic system whose response is describable in terms of the system's normal modes. Prediction methods are developed for structural responses, noise reduction and internal acoustic fields of untreated and acoustically treated fuselage structures. The results of this study have been programmed for computer solution, thus allowing the significant parameters affecting sound transmission to be determined. In addition to the computer programs, empirical design charts are presented for carrying out pre-design estimates of the external fluctuating loads due to boundary layer turbulence and jet noise and overall noise reduction of typical acoustic treatments. (Author).