The literature concerning cerebral circulation, its control, its relation to the metabolism of the brain and its disorders, including cerebral ischemia, is very large and reflects an interest which goes back to Greek and Arabian medicine and which has greatly intensified, particularly over the past decades. Data of the literature remain, however, too sparse to propose a pragmatic approach to cerebral ischemia when affecting people at young age. The first purpose of this monograph has been therefore to bring together from such a literature a coherent account of how present concepts and approaches have developed. In this, the authors have been guided by what seems to be the important lines of investigation. Secondly, the evidence from studies which form the basis of the present understanding has been reviewed critically and, where possible, an attempt has been made to pose present controversies in terms which would be helpful in everyday clinical practice.

The literature concerning muscle Glycogenoses reflects a world-wide interest which has been greatly intensified, mainly over the last ten years. To a large extent, this renewed interest is due to recent advances in diagnosing and treating the Lysosomal disease named Glycogenosis II or Pompe disease (GSD II). The new therapeutic approaches must induce us to make a great effort in order to better diagnose, treat and follow correctly the patients with Pompe disease. This book is a comprehensive text which covers all of the aspects regarding this disease, from pathogenic to clinical and therapeutic features.