Mike Knight, an executive in a semiconductor firm, learns that his eight-year-old son Tim has a rare form of brain cancer. Tim's best hope for long-term survival is a drug called Supragrel. Unfortunately, Supragrel is still in early clinical trials and may reach the market too late. Mike makes the agonizing decision to quit his job and go to work for Altus Labs, the developer of Supragrel, in hopes of helping them bring the drug to market more quickly. Mike is in for the challenge of his life as he struggles to keep his family together while racing against time to implement world-class project management in Altus Labs. Critical Chain Project Management is a superior project management process that has been quietly implemented in some of the world's best-known companies for over a decade. This book tells you the story of a Critical Chain Project Management implementation. The venue is a major pharmaceutical company, but it could happen anywhere in corporate America.

Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.

Mike Knight, an executive in a semiconductor firm, learns that his eight-year-old son Tim has a rare form of brain cancer. Tim's best hope for long-term survival is a drug called Supragrel. Unfortunately, Supragrel is still in early clinical trials and may reach the market too late. Mike makes the agonizing decision to quit his job and go to work for Altus Labs, the developer of Supragrel, in hopes of helping them bring the drug to market more quickly. Mike is in for the challenge of his life as he struggles to keep his family together while racing against time to implement world-class project management in Altus Labs. Critical Chain Project Management is a superior project management process that has been quietly implemented in some of the world's best-known companies for over a decade. This book tells you the story of a Critical Chain Project Management implementation. The venue is a major pharmaceutical company, but it could happen anywhere in corporate America.

Wie sind die Texte aus Richter 3,7 - 8,35 entstanden, welche religionsgeschichtliche Wirklichkeit spiegeln sie wider, und welche theologischen Intentionen sind in ihnen lebendig? Die vorliegende Studie bemüht sich auf der Grundlage einer eingehenden exegetischen Untersuchung um die Beantwortung dieser drei für das Verständnis und die Deutung zentraler Partien des Richterbuches entscheidenden Fragen.