The incidence of metastatic disease in the central nervous system (CNS) is rising. According to current estimates, up to a third of adult cancer patients will suffer from CNS metastasis. Clinical evidence-based data from prospective randomized trials are rare, however, because CNS metastasis patients were often excluded from clinical trial participation. The management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary challenge. Recent basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the CNS. This report reviews advances, challenges, and perspectives in this field.

The Atlas of Breast Surgery presents the anatomy, diagnostic procedures, and step-by-step guidelines necessary for plastic surgeons, oncologists, and general surgeons to correctly and successfully perform surgical procedures on the breast. This excellent clinical reference is a superb work of art with stunning drawings and systematic tabular presentations that enhance the text. The clear and uncomplicated design will help surgeons master procedures quickly and efficiently. Key Features: More than 200 outstanding high-quality watercolor drawings Edited by internationally renowned experts on breast surgery Modern approach, emphasizing breast-conserving strategies where oncologically feasible and in the best interests of patients Detailed, point-by-point descriptions of routine as well as more complex surgical procedures Comprehensive coverage of esthetic and reconstructive techniques as well as essential procedures for the diseased breast Plastic surgeons, oncologists, and general surgeons treating patients indicated for breast surgery will undoubtedly want to refer to this atlas repeatedly in the course of their daily practice, and it is sure to become a treasured volume in their medical library for many years. As such, it constitutes a worthy and fitting companion volume to Thieme's celebrated Atlas of Gynecologic Surgery, now in its fourth edition.

A groundwork and milestone for an innovative, trendsetting, and international school of thought in gynecology. A superb work of art as well as an outstanding clinical reference, this book continues the rich tradition of earlier editions by providing unparalleled coverage of the entire field of gynecologic surgery. This new fourth edition offers completely updated content, user-friendly features, and the cornerstone of the book: an art program of astounding quality. It is indispensable for gynecologic surgeons or residents who need to review, refresh, or fine-tune their skills in preparation for surgery, while being alerted to pitfalls and possible complications at every juncture. Special features of the new 4th edition of this world-famous atlas: Nearly 1,200 stunning watercolor drawings that provide a visual depiction of operative steps unequalled in the literature Detailed, point-by-point descriptions of routine as well as more complex procedures Full coverage of abdominal, vaginal, and endoscopic approaches in sections on the adnexa, uterus, vulva/vagina, and pelvic floor Introduction of the new "Procedure Navigator" section, which facilitates a convenient search from disease to indication to medical or surgical treatment of choice A truly international perspective, with leading specialists from Europe and the United States sharing heir clinical experience and wisdom Complete with expert foundational chapters on pre- and postoperative treatment, informed consent, instrumentation, indications and contraindications, risks and complications, and more, this book is both beautiful and informative. Its step-by-step didactic concept is ideal for residents-in-training, while its detailed description of both common and rare procedures makes it useful for experienced surgeons. For all specialists, Atlas of Gynecologic Surgery is a standard, must-have reference on curren

Abstract: Introduction Since 01/01/2020, the cervical cancer screening in Germany has been carried out due to the organized early cancer diagnosis guideline (oKFE-RL). In 2007, HPV vaccination was initiated in Germany. The main goal of both initiatives is to further reduce the incidence of invasive cervical cancer. To assess the effect of the new screening strategy in a timely manner, monitoring of short-term changes need to be considered. Ideally, the effects of both prevention methods would be presented together in one model. Materials and methods Because no change in the incidence of invasive cervical cancer is initially expected, the incidence of CIN 3 is used as a surrogate parameter to assess the effects of the prevention efforts. Based on expected additional effects of vaccination and co-testing, a model-based estimation of the expected CIN 3 incidence during the evaluation of the screening program is performed using the CIN 3 incidence in the Saarland population. Modeling results The oKFE-RL provides for two groups: Primary cytodiagnosis continues until 35 years of age. Here, in the next few years, CIN 3 incidence will be reduced not by the oKFE-RL but by the increasing proportion of vaccinated women. In the group over 35 years, co-testing was introduced with a stringent algorithm. Due to the higher sensitivity of the HPV test, significantly more CIN 3 are detected in the first round of 3 years and thus, the CIN 3 incidence initially increases. As these CIN 3 are absent in the second round, significantly fewer CIN 3 cases will be detected then. These effects suggest a global decrease in CIN 3 incidence of 25.8% after 6 years. Conclusion Observation of the age distribution curve of CIN 3 allows both effects of prevention to be assessed in a timely manner and separately. In the future, data from epidemiologic cancer registries should be incorporated into the model to replace modeling with real data

Die komplette gynäkologische Endoskopie - angelehnt an die aktuellen Kurse der DGGG. Dieses Buch zeigt Ihnen Schritt-für-Schritt, wie Sie minimal-invasive Eingriffe durchführen: - endoskopische Grundlagen und Instrumentenkunde - Schritt-für-Schritt-Darstellung aller gängigen operativen Verfahren - brillante Abbildungen erleichtern die Orientierung - exakte Handlungsanweisungen für Diagnostik und Therapie.