Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

An anthology of Amish and Christian romances... Her mother had always told Rachel, "Darling, divorce is for the weak that do not honor the decisions of our maker," whenever they heard community news or gossip about a broken marriage or divorce. It was just not something that her mother believed should be done - under any circumstances. And Rachel lived to please others. It was just the way that God had made her. She did not want to let her mother down. She did not want to let her community down. She did not believe for a minute that women that chose divorce were weak or sinful, but she feared the pain of being judged as weak. She feared the disappointment that she would incite in her family, especially her mother, if that would ever be something that she would need to consider...But what if it became the only option?

An anthology of Amish mystery and sweet romance...Rachel was subject to daily abuse by her husband John. But the fear of being shunned after getting a divorce was more than she could take...so she endured...Her friend encourages her to leave...and one night she is beaten so severely that she has to be taken to the hospital.But when she arrives home, she finds her husband murdered and fingers are pointed around the Amish community. Could it be Samuel? The man who always pined for her. Or could it be her father who never liked her husband to begin with?

Rachel was subject to daily abuse by her husband John. But the fear of being shunned after getting a divorce was more than she could take...so she endured...Her friend encourages her to leave...and one night she is beaten so severely that she has to be taken to the hospital...But when she arrives home, she finds her husband murdered and fingers are pointed around the Amish community. Could it be Samuel? The man who always pined for her. Or could it be her father who never liked her husband to begin with?

Desperate Housewives on your hand! Each coloring page is printed on a separate sheet to avoid bleed through

Her mother had always told Rachel, "Darling, divorce is for the weak that do not honor the decisions of our maker," whenever they heard community news or gossip about a broken marriage or divorce. It was just not something that her mother believed should be done - under any circumstances. And Rachel lived to please others. It was just the way that God had made her. She did not want to let her mother down. She did not want to let her community down. She did not believe for a minute that women that chose divorce were weak or sinful, but she feared the pain of being judged as weak. She feared the disappointment that she would incite in her family, especially her mother, if that would ever be something that she would need to consider...But what if it became the only option?