Cystic fibrosis (CF) is one of the most common fatal autosomal recessive hereditary disease in Caucasian population, with a carrier frequency of 1 in 25, and with a disease frequency of approximately 1 in 2000 live-born children. CF affects tissues that produce mucus, these are airway, gastriontestinal tract, pancreatic and hepatobiliary ducts, liver and male urogenital tract. Severe classical form of CF is characterized by elevated sweat electrolyte levels, chronic sinopulmonary disease, and pancreatic insufficiency. Approximately 95 % of men with CF are infertile due to the congenital bilateral absence of the vas deferens (CBAVD). The gene responsiblefor CF (Cystic Fibrosis Transmembrane conductance Regulator - CFTR)was cloned and characterized in 1989. Almost 900 different mutations havebeen identified in CFTR gene of patients affected with CF. The most commonmutation in CFTR protein is a deletion of phenylalanine at position 508 (F508). This deletion is present in 68 % of CF chromosomes worldwide. Due to many known diseases (neonatal meconium ileus, liver cirrhosis, bilateral and unilateral absence of the vas deferens, as well as diabetes, pancreatitis, and Crohn's disease), which share some clinical features with CF, researchers started to study the involvement of alterations in CFTR gene in these diseases. One of first such connections was discovered in 1992, when it was found out that aproximatelly 70 % of otherwise healthy men but infertile due to CBAVD had mutations in the CFTR gene. There were studies that confirmed butalso denied the involvement of CFTR gene in male infertility in the beginning of our research in 1997. In the Department of obstetrics and Gynecology in Ljubljana a ICSI (Intracytoplasmic Sperm Injection) methode was applied in 1995. So we wanted to clarify the involvement of CFTR gene in infertile men who were indicated for ICSI methode. (Abstract truncated at 2000characters).

Vojaška obveščevalna, protiobveščevalna in varnostna dejavnost (VOPVD) združuje obveščevalno, protiobveščevalno in varnostno dejavnost, ki skupaj uresničujejo obveščevalno zagotovitev. Obveščevalna zagotovitev zagotavlja možnost pravočasne, načrtne in organizirane priprave namensko oblikovanih enot za izvedbo svojega poslanstva v celotnem spektru delovanja. Obveščevalna zagotovitev je bojna funkcija, ki jo vodi in usmerja poveljnik, izvajajo jo obveščevalno varnostni organi (S-2) brigade in polkov, obveščevalna četa, izvidniške enote, manevrske enote (bataljoni in čete). Je neprekinjena dejavnost medsebojno povezanih nalog in sistemov, ki skozi obveščevalni proces, z načrtovanjem in usmerjanjem, zbiranjem in obdelavo pomembnih informacij v obveščevalni podatek oziroma znanje ter njegovim posredovanjem poveljniku omogočajo razumevanje sovražnika, zemljišča in civilnih dejavnikov. Učinkovito obveščevalno zagotovitev v kompleksnem, dinamičnem in soodvisnem okolju obveščevalni elementi v polku in brigadi izvajajo s pomočjo vseh razpoložljivih sredstev in virov. Organizacijska struktura VOPVD v brigadi in polku mora omogočati odzivno in pravočasno obveščevalno podporo ter hitro premestljive obveščevalne elemente, ki bodo prožni in sposobni delovati v celotnem spektru možnih operacij kjerkoli po svetu.