The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

Making extensive use of information gained from in-depth interviews with architects active in the period between 1928-1953, the author provides a sympathetic understanding of the Modern Movement's architectural role in reshaping the fabric and structure of British metropolitan cities in the post-war period and traces the links between the experience of British modernists and the wider international modern movement.

How can the industrialized countries reduce their vulnerability to supply disruptions caused by continued dependence on foreign sources of oil? How can access to Middle East oil be made more secure? These are the core questions that arise from a new worldwide energy situation in which the industrialized countries have remained dependent on oil and oil imports for their economic, political, and military well-being, while control of these resources has passed to an increasingly small number of less-developed countries whose interests do not automatically or necessarily coincide with those of the consuming, industrialized countries. With a focus on these questions, The Geopolitics of Energy analyzes the present worldwide energy situation and its likely evolution over the remainder of the century. The authors consider likely developments in coal, gas, and nuclear energy; the outlook for oil, which will remain the dominant energy source at least through the 1990s; and the implications of this energy outlook for U.S. foreign policy, intra-Western alliance relations, and North-South and East-West relations. Identifying the issues that will concern governments as long as the need for oil is pervasive-until alternative energy sources begin contributing significantly to world energy supply-the authors conclude with policy recommendations for the United States based on their analysis of the energy situation and its consequences. This book is based on a report prepared for the U.S. Department of Defense.

Author Jerold Gold reviews the progress that has been made in the field of integrative psychotherapy. The author develops a unique narrative-based framework in which clinicians can synthesize different psychotherapies into an integrated conceptual system and technical method. An ongoing case example illustrates the framework and its key concepts. In addition, chapters examine the contributions of psychodynamic, humanistic, cognitive-behavioral, and integrative therapies to the development of important psychotherapeutic ideas.

Festivals have always been part of city life, but their relationship with their host cities has continually changed. With the rise of industrialization, they were largely considered peripheral to the course of urban affairs. Now they have become central to new ways of thinking about the challenges of economic and social change, as well as repositioning cities within competitive global networks. In this timely and thought-provoking book, John and Margaret Gold provide a reflective and evidence-based historical survey of the processes and actors involved, charting the ways that regular festivals have now become embedded in urban life and city planning. Beginning with David Garrick’s rain-drenched Shakespearean Jubilee and ending with Sydney’s flamboyant Mardi Gras celebrations, it encompasses the emergence and consolidation of city festivals. After a contextual historical survey that stretches from Antiquity to the late nineteenth century, there are detailed case studies of pioneering European arts festivals in their urban context: Venice’s Biennale, the Salzburg Festival, the Cannes Film Festival and Edinburgh’s International Festival. Ensuing chapters deal with the worldwide proliferation of arts festivals after 1950 and with the ever-increasing diversifycation of carnival celebrations, particularly through the actions of groups seeking to assert their identity. The conclusion draws together the book’s key themes and sketches the future prospects for festival cities. Lavishly illustrated, and copiously researched, this book is essential reading not just for urban geographers, social historians and planners, but also for anyone interested in contemporary festival and events tourism, urban events strategy, urban regeneration regeneration, or simply building a fuller understanding of the relationship between culture, planning and the city.

City authorities in recent years have competed vigorously to gain the right to host international festivals. In doing so they are heirs to a long tradition, since cities have always served as a natural location for festivals and fairs, providing settings on a scale impossible elsewhere. Cities of Culture examines the role of the Western city as the scene of staged cultural events over the last 150 years. Adopting a lively comparative perspective, it highlights the development of international festivals since London's Great Exhibition of 1851. Making extensive use of case studies and illuminating examples, it offers thought-provoking insight into the material and symbolic significance of international festivals in urban affairs. The book opens with an historical analysis of the role of the city as centre for celebrations, rites and festivities from Antiquity to the French Revolution. The next three sections of the book each focus on a different form of international festival. The first deals with the history of staging the International Expositions, with case studies of the Great Exhibition (1851), New York's World's Fair (1939-40) and Montreal's Expo 67 (1967). The next part covers the Summer Olympic Games from their revival at Athens in 1896 to the Atlanta Games (1996), discussing the implications of their fluctuating fortunes for their host cities. The third section discusses the history of a recently-founded event that is assuming ever-greater importance - the European Cities of Culture programme. The conclusion provides an overview of the events that celebrated the Millennium and examines the prospects for international festivals as part of the urban agenda of the twenty-first century. Cities of Culture will appeal to students of cultural history, urban and cultural geography, specialists in arts and heritage events management, and anyone with an interest in the development of the contemporary Western city.