Jetzt auch für den Förderschwerpunkt geistige Entwicklung: ganz einfache Lapbooks zum Schneiden, Falten, Gestalten und Präsentieren! Lapbooks eignen sich sehr gut für die Arbeit mit Schülerinnen und Schülern im Förderschwerpunkt geistige Entwicklung, da sie eine intensive Auseinandersetzung mit verschiedenen Unterrichtsinhalten ermöglichen. In diesem E-Book finden Sie methodisch-didaktische Hinweise und Vorlagen für Lapbooks zu motivierenden Themen aus dem Schulalltag, zum Beispiel „Morgenkreis“, „Meine Woche“ und „Meine Klasse“. Zu jedem Lapbook gibt es verschiedene Elemente, die von den Schülerinnen und Schülern größtenteils individuell gestaltet werden können („Das gefällt mir“, „Meine Schulfreunde“, „So drücke ich mich aus“). Weitere Elemente dienen der Strukturierung des Schultages („Welcher Tag ist heute?“, „Stundenplan“). So bietet jedes individuelle Lapbook vielfältige Kommunikationsanlässe. Hinweise zur Erstellung der Lapbooks mit motorisch eingeschränkten Schülerinnen und Schülern runden das Paket ab.

Abstract: Background and Aims Dual immune checkpoint blockade (ICB) therapy can result in immune-related-adverse events (irAE) such as ICB-hepatitis. An expansion of effector-memory (TEM) CD4 T cells associated with antiviral immunity against herpesviridae was implicated in ICB-hepatitis. Notably, these memory subsets are frequently associated with age. Here, we sought to understand baseline patient, immune and viral biomarkers associated with the development of ICB-hepatitis to identify currently lacking baseline predictors and test if an expansion of TEM or positive serology against herpesviridae can predict ICB-hepatitis. Methods A discovery (n = 39) and validation cohort (n = 67) of patients with advanced melanoma undergoing anti-PD-1&anti-CTLA4 combination therapy (total n = 106) were analyzed for baseline clinical characteristics, occurrence of irAE and oncological outcomes alongside serological status for CMV, EBV and HSV. Immune populations were profiled by high-parametric flow cytometry (n = 29). Results ICB-hepatitis occurred in 59% of patients within 100 days; 35.9% developed severe (CTCAE 3-4) hepatitis. Incidence of ICB-hepatitis was higher in the younger ( 55y: 85.7%) compared to older ( = 55y: 27.8%) age group (p = 0.0003), occured earlier in younger patients (p 0.0001). The association of younger age with ICB-Hepatitis was also observed in the validation cohort (p = 0.0486). Incidence of ICB-hepatitis was also associated with additional non-hepatic irAE (p = 0.018), but neither positive IgG serostatus for CMV, EBV or HSV nor TEM subsets despite an association of T cell subsets with age.brConclusionbr

This internship report is a review of my time in Peru on a Rotary International Ambassadorial Scholarship where I studied for two semesters at La Pontificia Universidad Católica del Perú (PUCP) starting in February of 2006. In Peru I participated in a project sponsored by the National Geographic Committee for Research and Exploration called Proyecto Desierto Verde (Project Green Desert) headed by Dr. Kai Tiedemann and Anne Lummerich. Project Green Desert was a pilot project that used fog collectors as an instrument for creating green community spaces. The project was directed toward the women of marginalized communities on the outskirts of Lima and worked to create a means of self-employment for them. The science of fog collection and a review of Project Green Desert are discussed.