Alzheimer's disease is a devastating disease, affecting millions. There is some familial evidence of an inheritance pattern from a genetic basis in Alzheimer's disease patients, but even with revelation of the genetic linkage and genes associated with Alzheimer's disease, the inheritance pattern is too complicated to be properly explained. It is necessary to investigate other causes of the debilitating disease. To investigate further, the epigenome was studied - the regulation of the genome by methyl group addition. To study the epigenome of an Alzheimer's disease-like state, isoschizomer enzymes were used to cleave CC*GG regions. Comparing the cleaved DNA sequences produced allowed for determination of the methylation status of the CC*GG. The methylation statuses of differentiated neuroblastoma cells and amyloid-B peptide was observed. Increased complexity was observed in the amyloid-B treated neuron-like sample; the less complex differentiated sample and the even less complex undifferentiated sample showed that the methylation levels differ between cell types. These observations can be confirmed in the future by investigation of individual gene loci to confirm spikes or drops in methylation. Additional future studies include ontological analysis, using Genecodis (http://genecodis2.dacya.ucm.es/), to search for the specific DNA methylation regions (2).

Life's evolving and exiting windows bring about rainstorms and rainbows in everyone of our lives with no umbrellas or warnings.The two sisters in the first story Angela and Angel hopes for love again while journeying devastating trials, forgiveness of the unthinkable and massive loss. In the second story Rachael the critical, sharp and beautiful matriarch of three daughters Trina, Tracy and Sheila raises her girls to be nothing less than the two divines Elizabeth Taylor and Oprah Winfrey.The girls give her a shock of the real world and a lesson on what really matters for the acquiring of one's gain in material and monetary does not supersede over one's peace of mind.

In life there's a pro and a con, an in and an out, a right and a wrong, a yes and a no,a dark and a light,a cost and a price,a beginning and an end and in this story traveling into the journey of Paris France a beautiful and only child raised by her grandmother,after the demise of her mother,Paris in a lot of ways was like her mother sensual and deadly in which she tried to escape the sometimes strain of beauty but sometimes it takes more than trying to overcome something bigger than yourself which can lead to dissolution.