The subject of the invention is a process device for coating particles that falls within the field of chemical and pharmaceutical technology. It represents an improvement on the process equipment for coating particles by spraying from the bottom and works on the principle of fluidization technology. The process device for coating particles, according to the invention which has within the wall (1), one or more units placed, for which each unit consists of a swirl flow generator (4) with a perforated plate (3) and a draft tube (5) where centrally through the swirl flow generator (4) a single or multi-phase spraying nozzle (6) with a coating dispersion inflow (7) and inflow (8) of compressed air is installed, in which the swirl flow generator (4) has outward open and at an angle with regard to the vertical installed grooves (18).; The process device for coating particles in the second implementation case, has within the wall (1), one or more units placed, for which each unit consists of a draft tube (5) and a single or multi-phase spraying nozzle (6), which is mounted centrally with regard to the draft tube (5) and penetrates the perforated plate (3a). The perforated plate (3a), which is in the outer area, between the wall of the draft tube (5), and the wall (1) of the device, in cross-section straight or curved and has a characteristic distribution of the size of round orifices with the largest cross sections in the area of the ground floor projection of the draft tube (5) and smaller orifices in the remaining part of the plate.; The device for coating shall have along the periphery of the wall (1) and at the perforated plate (3a) the ring (21) with installed inflow slots (27) that are pressure powered from a common hollow ring (20) with a connector (22) for compressed air. The device for coating shall have along the periphery of the wall (1) above the perforated plate (3a) a radially installed circumferential inflow slot (24) and otherwise inclined to the horizontal plane, the slot (24) is pressure powered through the hollow ring (23) with a pressure connection (25).

The present invention relates to the pharmaceutical dosage forms which enabled a controlled and/or a targeted drug delivery of an active substance tothe selected regions of gastrointestinal tract of humans or animals. The pharmaceutical dosage forms preferably comprises the active substance N-(2(2phthalimidoethoxy-acetyl)-L-alanyl-D-glutamic acid (designed as LK-423).Methods of treatment of chronic inflammatory diseases of gastrointestinal tract of humans and/or animals by using the pharmaceutical dosage forms of the invention are disclosed.

The subject of the invention is a process device for coating particles that falls within the field of chemical and pharmaceutical technology. It represents an improvement on the process equipment for coating particles by spraying from the bottom and works on the principle of fluidization technology. The process device for coating particles, according to the invention which has within the wall (1), one or more units placed, for which each unit consists of a swirl flow generator (4) with a perforated plate (3) and a draft tube (5) where centrally through the swirl flow generator (4) a single or multi-phase spraying nozzle (6) with a coating dispersion inflow (7)and inflow (8) of compressed air is installed, in which the swirl flow generator (4) has outward open and at an angle with regard to the vertical installed grooves (18).

Pharmaceutical composition comprising a solid matrix system of quetiapine or its salt and a nonswellable anionic polymer.

In the present invention novel sustained release pharmaceutical composition isdescribed comprising quetiapine and carrageenan.