Background: In so called "high volume" institutions with great experience in gastric surgery an expected 5-year survival for patients after gastric resection treated for gastric cancer is 40-50 %. Prognostic factors are factors that influence the prognosis of the disease. The aim of the study was to verify the classic clinico-pathological prognostic factors of the expected survival, to determine the frequency of imunohistochemical factors (C-erB-2, p53 and bcl-2) and to verify this imunohistochemical factors in its function as prognostic factors in gastric cancer patients after potentially curative gastric resection (R0) has been performed. The aim of the study was to determine the frequency of imunohistochemical factors (p53, bcl-2 in C-erB-2) in tumor tissue and to prove their role as a prognostic factor in a univariate and multivariate analysis. Classical clinicopathological factors were analysed in the same way. Methods: In a retrospective study, prospectively collected data of 81 patients operated with a potentially curative resection for gastric cancer in 4 year period (from 01. 01. 1995 to 31. 12. 1998), were analyzed. Clinico-pathological factors which were analyzed in univariate analysis were age, gender, diameter of the tumor, grade of differentiation, Lauren histological classification, deepness of invasion, metastatic implementation of lymph nodes, and tumor stage according to UICC. Imunohistochemical factors we studied in a univariate analysis were: C-erbB-2, p53 and bcl-2. Clinico-pathological and imunohistochemical factors were further analyzed in a multivariate analysis. Statistical methods: [Chi] test, t-test (Student's test), Kaplan-Meier's method of calculation of survival and life tabels, Log-Rank test, Cox's regression method; A SPSS 10-0 program was used for statistical calculation. Results: The majority of patients (86.5 %) were older than 50 years. The study showed the age and ASA to be important prognostic factors (p0.05 for age and ASA). According to present study the UICC stage is the most significant prognostic factor (p