More than ten years have elapsed since the publication of a compre hensive review on the quassinoids, the bitter principles of the Simaroubaceae family (80). Interest in these terpenoids has increased enormously in recent years due in part to the finding of the American National Cancer Institute in the early 1970s that these compounds display marked antileukemic activity. Furthermore, a wide spectrum of other biological properties for the quassinoids has been discovered and studies on chemical modifications of inactive members to yield biologically active ones were undertaken. New structures have been established also and numerous synthetic approaches have been developed which include the total synthesis of the parent compound, quassin (p. 250) and also that of castelanolide (p. 253). It is intended that this present chapter will be an extension of my first review in this series and will contain references up to September 1984. A short article on some aspects of this subject was published recently (81). II. Quassinoid General Features In reviewing the essential features of the quassinoids, the new structural types discovered during the last decade will be emphasised. The quassinoids can be divided into distinct groups according to their basic skeletons. The five skeletons observed are presented on Chart 1.

U.S. policy toward the Central Asian states has aimed at facilitating their cooperation with U.S. and NATO stabilization efforts in Afghanistan and their efforts to combat terrorism, proliferation, and trafficking in arms, drugs, and persons. Other U.S. objectives have included promoting free markets, democratization, human rights, energy development, and the forging of East-West and Central Asian-South Asian trade links. Such policies aim to help the states become what various U.S. administrations have considered to be responsible members of the international community rather to degenerate into xenophobic, extremist, and anti-Western regimes that contribute to wider regional conflict and instability. This book examines the recent developments in Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan with a focus on the emerging importance of the U.S.-Central Asia partnership.