Neue Erkenntnisse in der Neuro- und Molekularbiologie, der Epigenetik und Entwicklungspsychologie sowie der Psychotherapie- und der Stressforschung haben zu einem weitreichenden Paradigmenwechsel in der Psychosomatischen Medizin geführt. Dieses Lehr- und Handbuch bietet in 100 Kapiteln zunächst eine aktuelle Bestandsaufnahme der wissenschaftlich gesicherten bio-psycho-sozialen Grundlagen dieser neuen Psychosomatik, um darauf aufbauend die Diagnostik und Therapie der wichtigsten psychosomatischen Erkrankungen umfassend darzustellen. Ergänzt wird dies durch Beiträge zur Geschichte der Psychosomatik, Epidemiologie, Gesundheitsökonomie, psychosozialen Prävention, Sozialmedizin und Begutachtung. Die 2. Auflage wurde um Kapitel zu assoziativen Lern- und Gedächtnisprozessen, PTBS, Diabetes mellitus Typ 2, Asthma, COPD, funktionellen Atemwegserkrankungen sowie Placebo- und Nocebo-Effekten erweitert. Dieser umfassende, systematische und empirisch fundierte Überblick über die gesamte Psychosomatik hat sich als modernes Standardwerk für das Studium, die Aus- und Weiterbildung sowie die klinische Praxis etabliert.

The numerous findings on the development of attachment that have been published in the field of developmental psychology over many decades, along with the attachment theory developed by John Bowlby, are now also being accepted in clinical psychology, psychotherapy and medicine. This handbook sums up the findings on the importance of attachment in various phases of life, as well as the result of clinical research on attachment in relation to psychological and physical disturbances. The special relevance of the theory lies in its fields of application - in prevention and in psychotherapy in various treatment settings.

Abstract: Background The EQ-5D and the SF-6D are examples of commonly used generic preference-based instruments for assessing health-related quality of life (HRQoL). However, their suitability for mental disorders has been repeatedly questioned. Objective To assess the responsiveness and convergent validity of the EQ-5D-3L and SF-6D in patients with depressive symptoms. Methods The data analyzed were from cardiac patients with depressive symptoms and were collected as part of the SPIRR-CAD (Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease) trial. The EQ-5D-3L and SF-6D were compared with the HADS (Hospital Anxiety and Depression Scale) and PHQ-9 (Patient Health Questionnaire) as disease-specific instruments. Convergent validity was assessed using Spearman's rank correlation. Effect sizes were calculated and ROC analysis was performed to determine responsiveness. Results Data from 566 patients were analysed. The SF-6D correlated considerably better with the disease-specific instruments (|rs|= 0.63-0.68) than the EQ-5D-3L (|rs|= 0.51-0.56). The internal responsiveness of the SF-6D was in the upper range of a small effect (ES: − 0.44 and − 0.47), while no effect could be determined for the EQ-5D-3L. Neither the SF-6D nor the EQ-5D-3L showed acceptable external responsiveness for classifying patients' depressive symptoms as improved or not improved. The ability to detect patients whose condition has deteriorated was only acceptable for the EQ-5D-3L. Conclusion Overall, both the convergent validity and responsiveness of the SF-6D are better than those of the EQ-5D-3L in patients with depressive symptoms. The SF-6D appears, therefore, more recommendable for use in studies to evaluate interventions for this population