Patients involved in major trauma frequently suffer from severe blood loss and anemia, which can be challenging to treat. Additional issues are presented in the population of Jehovah’s Witness patients, who refuse transfusions of allogenic blood or its components. We established a stable hemodynamic status in a young Jehovah’s Witness patient with major trauma by applying principles of patient blood management. About the Patient Blood Management Case Report Series Patient Blood Management (PBM) is a multidisciplinary, evidence-based approach to improve perioperative patient care. The concept includes preoperative screening, diagnosis and treatment of anemia and hemostasis, adequate blood product utilization and blood-sparing techniques. The use of a PBM concept will be of benefit for patients, society, doctors and hospitals. The case reports in this series will provide a case-based deeper understanding of the concept.

This case report describes the poor outcome of a female patient who underwent elective nephrectomy. Unfortunately, the patient was suffering from undiagnosed preoperative platelet dysfunction and anemia, although blood count and clotting were almost within normal ranges two weeks earlier at the day of preoperative assessment for anesthesia. In this respect, intensive preoperative evaluation of the coagulation system embedded in a comprehensive patient blood management (PBM) concept might have the potential to detect preoperative coagulopathy and anemia and thereby could improve clinical outcome. About the Patient Blood Management Case Report Series Patient Blood Management (PBM) is a multidisciplinary, evidence-based approach to improve perioperative patient care. The concept includes preoperative screening, diagnosis and treatment of anemia and hemostasis, adequate blood product utilization and blood-sparing techniques. The use of a PBM concept will be of benefit for patients, society, doctors and hospitals. The case reports in this series will provide a case-based deeper understanding of the concept.

This book gives a brief overview of the "Patient Blood Management" (PBM) concept and is addressed to health professionals as well as all persons generally involved into hospital management. "Patient Blood Management" (PBM) is a multidisciplinary, evidence-based approach to improve perioperative care. The concept is based on three pillars that target modifiable risk factors for adverse outcome: i) preoperative screening, diagnosis and treatment of anaemia, ii) blood-sparing techniques, and iii) adequate blood product utilization. The superior objective is to optimize patient outcome. Anaemia is common among hospital patients and an underestimated risk factor for blood transfusions, higher morbidity and mortality. Optimizing and preserving red cell mass before, during and after surgery can be achieved by a number of measures that can be implemented in EVERY hospital. These measures have high potential to improve patient outcome and to reduce costs both for allogeneic blood transfusions and for the treatment of the associated complications. Furthermore, due to the current demographical development, the offer of available blood products is most likely to decrease in the future whilst advances in modern medicine increase blood product demands, thus causing scarcity. Therefore, it is our duty towards society, patients and donors to use blood products wisely and only when absolutely necessary. Patient Blood Management is our strategy to face this challenge. The use of a PBM concept will be of benefit for patients, society, doctors and hospitals. This book, written by the key members of the University Hospital Frankfurt PBM project, aims to give a deeper understanding of the three pillars of the concept, and provide insights for undertaking further research as well as planning and implementing concrete operative measures.

Auch für erfahrene Anästhesisten gibt es immer wieder Überraschungen und besondere Situationen, die nicht in Lehrbüchern abgehandelt werden können, aber im OP schnelle Lösungen verlangen. Lernen Sie aus den Erfahrungen anderer. In diesem Titel werden 100 spannende und besonders einprägsame Fälle geschildert. Pro Fallbericht werden Situation, Fehlhandlungen oder Fehleinschätzungen differenziert analysiert und Empfehlungen für ein professionelles Fehlermanagement gegeben.

Auch für erfahrene Anästhesisten gibt es immer wieder Überraschungen und besondere Situationen, die nicht in Lehrbüchern abgehandelt werden können, aber im OP schnelle Lösungen verlangen. Lernen Sie aus den Erfahrungen anderer. In diesem Titel werden 100 spannende und besonders einprägsame Fälle geschildert. Pro Fallbericht werden Situation, Fehlhandlungen oder Fehleinschätzungen differenziert analysiert und Empfehlungen für ein professionelles Fehlermanagement gegeben.

Alterstraumatologische Verletzungen und orthopädische Eingriffe bei betagten Patienten nehmen in Deutschland durch den demografischen Wandel dramatisch zu. Um dieser Herausforderung zu begegnen und die Versorgung zu verbessern, entstehen zunehmend Zentren, in denen ältere Patienten durch Orthopäden und Unfallchirurgen gemeinsam mit Geriatern behandelt werden. Das Weißbuch zeigt die wichtigsten Schritte einer guten Versorgung von älteren unfallchirurgischen und orthopädischen Patienten auf und enthält konsentierte nationale Behandlungsempfehlungen der DGOU und DGG.

Abstract: Background In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial to prevent device-associated thrombosis and device failure, however, it is associated with bleeding complications. In COVID-19, additional pathologies, such as endotheliitis, may further increase the risk of bleeding complications. To assess the frequency of bleeding events, we analyzed data from the German COVID-19 autopsy registry (DeRegCOVID). Methods The electronic registry uses a web-based electronic case report form. In November 2021, the registry included N = 1129 confirmed COVID-19 autopsy cases, with data on 63 ECMO autopsy cases and 1066 non-ECMO autopsy cases, contributed from 29 German sites. Findings The registry data showed that ECMO was used in younger male patients and bleeding events occurred much more frequently in ECMO cases compared to non-ECMO cases (56% and 9%, respectively). Similarly, intracranial bleeding (ICB) was documented in 21% of ECMO cases and 3% of non-ECMO cases and was classified as the immediate or underlying cause of death in 78% of ECMO cases and 37% of non-ECMO cases. In ECMO cases, the three most common immediate causes of death were multi-organ failure, ARDS and ICB, and in non-ECMO cases ARDS, multi-organ failure and pulmonary bacterial ± fungal superinfection, ordered by descending frequency. Interpretation Our study suggests the potential value of autopsies and a joint interdisciplinary multicenter (national) approach in addressing fatal complications in COVID-19