Von Plus-Size zum Wohlfühlgefühl: Franziska Ludwig alias Franzellii hat es geschafft. "Klick" machte es im Jahr 2013, als sich Franziska ihre Urlaubsfotos ansah. Und zwar im Kopf. Denn: 120kg – das war schlimm. Die Thüringerin beschloss, ihre Lebensgewohnheiten radikal zu ändern und verlor mit ihren eigenen Rezepten 50 kg in eineinhalb Jahren. Die frisch gekochten Gerichte wurden auf dem eigenen Blog franzellii.com gepostet und Franzellii motivierte nicht nur sich selbst durch ihren immer erfolgreicher werdenden Blog, sondern inspirierte auch ihre Leser. Franzelliis Erfolgsrezepte gibt es nun in einem Kochbuch, das von der Smoothie Bowl bis hin zum 3-Gänge-Menü jede Menge Rezepte bereithält, mit denen das Wunschgewicht in greifbare Nähe rückt. Die Eckpfeiler von Franzelliis Wohlfühlernährung: Low Carb/ High Fat und immer frisch kochen. Schlank sein, abnehmen und das ohne Diät: Mit Freude am Kochen und Genießen und Franzelliis leichten Rezepten kann jeder seine Erfolgsstory schreiben.

Abstract: Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti-angiogenic potential, we have investigated whether Sema3f can be used to protect against subretinal neovascularization in two mouse models. Both in the very low-density lipid-receptor knockout (Vldlr−/−) model of spontaneous subretinal neovascularization as well as in the mouse model of laser-induced choroidal neovascularization (CNV), we found protective effects of Sema3f against the formation of pathologic neovascularization. In the Vldlr−/− model, AAV-induced overexpression of Sema3f reduced the size of pathologic neovascularization by 56%. In the laser-induced CNV model, intravitreally injected Sema3f reduced pathologic neovascularization by 30%. Combined, these results provide the first evidence from two distinct in vivo models for a use of Sema3f in protecting the outer retina against subretinal neovascularization

Abstract: Purpose: To compare spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) for imaging retinal capillary hemangioblastomas (RCHs) in von Hippel-Lindau disease (VHLD). Methods: Prospective single-center cross-sectional study. Tumor size (TS) of perfused RCHs was assessed clinically in relation to the optic disc size. For both technologies, SD-OCTA and SS-OCTA, corresponding images with a scan size of 3 × 3 mm2 and 6 × 6 mm2, respectively, were overlaid according to the set of marker positions to determine the TS. Results: From 200 patients with VHLD, 48 patients showed 84 RCHs. SD-OCTA images of 39 RCHs (46.4%) and SS-OCTA images of 48 RCHs (57.2%) were suitable for analysis. The average in OCTA-measured TS of 1.60 ± 2.58 mm2 (range, 0.01-10.43) was congruent to the clinically assessed TS in 81.3% of cases (r = 0.86, P 0.0001). TS measured in SD-OCTA compared to SS-OCTA showed similar values and a high correlation (all P 0.0001). Nevertheless, despite the similarities, a slight trend in SS-OCTA was observed whereby with increasing TS, an elevated TS was detected compared to SD-OCTA (3 × 3-mm2 scans: mean difference of 0.03 ± 0.04 mm2, 6 × 6-mm2 scans: 0.08 ± 0.19 mm2). However, within the same imaging technology method, TS values almost did not differ (SD-OCTA: mean difference of 0.01 ± 0.02 mm2, SS-OCTA: 0.001 ± 0.01 mm2).brbrConclusions: OCTA may serve as an additional tool for diagnosis and monitoring of RCHs. Nevertheless, due to the differences between the technologies, the values cannot be used interchangeably.