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Development of a Neurotoxicity Assay that is Tuned to Detect Mitochondrial Toxicants
Johannes Delp
, Melina Funke
, Franziska Rudolf
, Andrea Cediel
, Susanne Hougaard Bennekou
, Wanda van der Stel
, Giada Carta
, Paul Jennings
, Cosimo Toma
, Marcel Leist
· 2019
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Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons
Ilinca Suciu
, Johannes Delp
, Simon Gutbier
, Anna-Katharina Ückert
, Anna-Sophie Spreng
, Christiaan Karreman
, Falk Schreiber
, Ivana Celardo
, Ivano Amelio
, Marcel Leist
· 2023
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A High-throughput Approach to Identify Specific Neurotoxicants/ Developmental Toxicants in Human Neuronal Cell Function Assays
Johannes Delp
, Simon Gutbier
, Stefanie Klima
, Lisa Hölting
, Kevin Pinto-Gil
, Jui-Hua Hsieh
, Michael Aichem
, Karsten Klein
, Falk Schreiber
, Marcel Leist
· 2018
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Mapping the Cellular Response to Electron Transport Chain Inhibitors Reveals Selective Signaling Networks Triggered by Mitochondrial Perturbation
Wanda van der Stel
, Huan Yang
, Nanette G. Vrijenhoek
, Giulia Callegaro
, Giada Carta
, Johannes Delp
, Marcel Leist
, Bob van de Water
, Erik Hendrik Julius Danen
· 2022
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Functional and Mechanistic Approaches to Improve Neurotoxicity Predictions
Johannes Delp
· 2019
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Shortened Derivatives from Native Antimicrobial Peptide LyeTx I: In Vitro and in Vivo Biological Activity Assessment
Leonardo Lima Fuscaldi
, Joaquim Teixeira de Avelar Júnior
, Daniel Moreira Dos Santos
, Daiane Boff
, Vívian Louise Soares de Oliveira
, Karla Aparecida Guimarães Gusmão Gomes
, Rosana de Carvalho Cruz
, Patrícia Luciana de Oliveira
, Johannes Delp
, Marcel Leist
· 2021
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Pharmacological LRH-1/Nr5a2 Inhibition Limits Pro-inflammatory Cytokine Production in Macrophages and Associated Experimental Hepatitis
Juliane Schwaderer
, Truong San Phan
, Astrid Glöckner
, Johannes Delp
, Marcel Leist
, Thomas Brunner
, M. Eugenia Delgado
· 2020
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New Approach Methods Supporting Read-across: Two Neurotoxicity AOP-based IATA Case Studies
Wanda Van der Stel
, Giada Carta
, Julie Eakins
, Johannes Delp
, Ilinca Suciu
, Anna Forsby
, Andrea Cediel-Ulloa
, Marcel Leist
, Susanne Hougaard Bennekou
, Bob van de Water
· 2021
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Major Changes of Cell Function and Toxicant Sensitivity in Cultured Cells Undergoing Mild, Quasi-natural Genetic Drift
Simon Gutbier
, Patrick May
, Sylvie Berthelot
, Abhimanyu Krishna
, Timo Trefzer
, Mehri Behbehani
, Ljudmila Efremova
, Johannes Delp
, Gerhard Gstraunthaler
, Tanja Waldmann
, Marcel Leist
· 2018
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Prevention of Neuronal Apoptosis by Astrocytes Through Thiol-mediated Stress Response Modulation and Accelerated Recovery from Proteotoxic Stress
Simon Gutbier
, Anna-Sophie Spreng
, Johannes Delp
, Stefan Schildknecht
, Christiaan Karreman
, Ilinca Suciu
, Thomas Brunner
, Marcus Groettrup
, Marcel Leist
· 2018