The sudden death of a person caused by an arrhythmia that is induced by physical and/or emotional stress provoked by the criminal activity of another person is sometimes referred to as "homicide by heart attack." Published criteria for such an event relate to situations where no physical contact occurs between the perpetrator and the victim. Situations involving physical contact, but with absence of lethal injuries, are frequently treated in a similar fashion by forensic pathologists. Herein, we propose a set of modified criteria, which include cases where physical contact has occurred. Five examples of so-called "homicide by heart attack" are presented, including a 40-year-old man who was struck in the head with a wooden statue, a 74-year-old man who was punched in the jaw by a robber, a 66-year-old woman who was startled awake by a home-intruder, a 67-year-old woman who struggled with a would-be purse-snatcher in a parking lot, and a 52-year-old man who was in a physical altercation with a younger man. In each instance, autopsy revealed the presence of severe, underlying heart disease, as well as absence of lethal injuries. In each case, investigative information was such that the emotional and/or physical stress associated with the criminal activity of another individual was deemed contributory to the death. The presumed mechanism of death in each case was a cardiac dysrhythmia related to underlying heart disease, but initiated by the emotional and/or physical stress.

Key scientific results from recent experiments, modeling tools, and heavy ion accelerator research are summarized that explore ways to investigate the properties of high energy density matter in heavy-ion-driven targets, in particular, strongly-coupled plasmas at 0.01 to 0.1 times solid density for studies of warm dense matter, which is a frontier area in high energy density physics. Pursuit of these near-term objectives has resulted in many innovations that will ultimately benefit heavy ion inertial fusion energy. These include: neutralized ion beam compression and focusing, which hold the promise of greatly improving the stage between the accelerator and the target chamber in a fusion power plant; and the Pulse Line Ion Accelerator (PLIA), which may lead to compact, low-cost modular linac drivers.

Over the past two years noteworthy experimental and theoretical progress has been made towards the top-level scientific question for the U.S. program in Heavy Ion Fusion Science and High Energy Density Physics: ''How can heavy ion beams be compressed to the high intensity required to create high energy density matter and fusion conditions''? [1]. New results in transverse and longitudinal beam compression, beam-target interaction, high-brightness transport, beam production, as well as a new scheme in beam acceleration will be reported. Longitudinal and Transverse Beam Compression: The Neutralized Transport Experiment (NTX) demonstrated transverse beam density enhancement by a factor greater than 100 when an otherwise space-charge dominated ion beam was neutralized by a plasma source [2]. This experiment was followed by the Neutralized Drift Compression Experiment (NDCX) in which an ion beam was longitudinally compressed by a factor of 50 [3]. This was accomplished by applying a linear head-to-tail velocity ''tilt'' to the beam, and then allowing the beam to drift through a meter-long neutralizing plasma. In both the transverse and longitudinal experiments, extensive 3-D simulations, using LSP, were carried out, and the agreement with experiments was excellent [4]. A three-dimensional kinetic model for longitudinal compression was developed, and it was shown that the Vlasov equation possesses a class of exact solutions for the problem [5]. Beam-Target Interaction: We have also made significant progress in identifying the unique role ion beams can play in heating material to warm dense matter (WDM) conditions. We have identified promising accelerator, beam, and target configurations, as well as new experiments on material properties. It is shown that the target temperature uniformity can be maximized if the ion energy at target corresponds to the maximum in the energy loss rate dE/dX [6]. Ions of moderate energy (a few to tens of MeV) may be used. The energy must be deposited in times much shorter than the hydrodynamic expansion time (ns for metallic foams at 0.01 to 0.1 times solid density). Hydrodynamic simulations [7] have confirmed that uniform conditions with temperature variations of less than a few per cent can be achieved. High-Brightness Transport: Unwanted electrons can lead to deleterious effects for high-brightness ion beam transport. We are studying electron accumulation in quadrupole and solenoid beam transport systems. Electrons can originate from background gas ionization, from beam-tubes struck by ions near grazing incidence, and from end-walls struck by ions near normal incidence [8]. In parallel with the experimental campaign, we have developed and implemented in WARP 3D a new approach to large time-step advancement of electron orbits, as well as a comprehensive suite of models for electrons, gas, and wall interactions [9]. If sufficient electrons are accumulated within the beam, severe distortion of the beam phase space can result. Simulations of this effect have reproduced the key features observed in the experiments. Beam Production: The merging-beamlet injector experiment recently completed demonstrates the feasibility of a compact, high-current injector for heavy ion fusion drivers. In our experiment, 119 argon ion beamlets at 400 keV beam energy were merged into an electrostatic quadrupole channel to form a single beam of 70 mA. The measured unnormalized transverse emittance (phase space area) of 200-250 mm-mrad for the merged beam met fusion driver requirement. These measurements are in good agreement with our particle-in-cell simulations using WARP3D [10]. We have also completed the physics design of a short-pulse injector suitable for WDM studies. Beam Acceleration: A new concept for acceleration, the Pulse Line Ion Accelerator PLIA [11], offers the potential of a very low cost accelerator for WDM studies. It is based on a traveling wave structure, using a simple geometry with a helical conductor. We have obtained experimental verification of the predicted PLIA beam dynamics. Measured energy gain, longitudinal phase space, and beam bunching are in good agreement with WARP3D simulations. Computational Models and Simulator Experiments: The pioneering merger of Adaptive Mesh Refinement and particle-in-cell methods [12] underlies much of the recent success of WARP3D. BEST, the Beam Equilibrium Stability and Transport code was optimized for massively parallel computers and applied to studies of the collective effects of 3D bunched beams [13] and the temperature-anisotropy instability [14]. Space-charge-dominated beam physics experiments relevant to long-path accelerators were carried out on the recently completed University of Maryland Electron Ring, and on the Paul Trap Simulator Experiment at PPPL.

The heterozygous condition characterized by the presence of hemoglobin AS (sickle-cell trait) occurs in approximately 8% of the American black population. Unlike the homozygous state (sickle-cell disease), sickle-cell trait is not widely recognized as a cause of life-threatening illness or death despite over 30 case reports describing fatal or serious complications of exercise in young black males with this condition. These reports identify heat stress, dehydration, viral illness, and poor physical conditioning as factors which may contribute to exertional rhabdomyolysis and sudden death, suggesting multifactorial etiology. However, since sickling is known to occur postmortem, it remains controversial as to whether the pathogenesis of these exercise related deaths involves microvascular obstruction by sickled erythrocytes. We describe three young black individuals with no significant past medical history who died following physical exertion. In all three cases, postmortem hemoglobin electrophoresis demonstrated hemoglobin AS. In none of the cases was the body temperature found to be elevated. These cases serve to remind the forensic community that, in the proper setting, sickle-cell trait must be viewed as a potentially fatal disorder.

We report on an ongoing study on modular Heavy Ion Fusion drivers. The modular driver is characterized by 10 to 20 nearly identical induction linacs, each carrying a single high current beam. In this scheme, the Integrated Research Experiment (IRE) can be one of the full size induction linacs. Hence, this approach offers significant advantages in terms of driver development path. For beam transport, these modules use solenoids which are capable of carrying high line charge densities, even at low energies. A new injector concept allows compression of the beam to high line densities right at the source. The final drift compression is performed in a plasma, in which the large repulsive space charge effects are neutralized. Finally, the beam is transversely compressed onto the target, using either external solenoids or current-carrying channels (in the Assisted Pinch Mode of beam propagation). We will report on progress towards a self-consistent point design from injector to target. Considerations of driver architecture, chamber environment as well as the methodology for meeting target requirements of spot size, pulse shape and symmetry will also be described. Finally, some near-term experiments to address the key scientific issues will be discussed.